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Unit information: Clinical Transfusion and Transplantation (TTS-B2) in 2015/16

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Unit name Clinical Transfusion and Transplantation (TTS-B2)
Unit code PANMM0019
Credit points 20
Level of study M/7
Teaching block(s) Teaching Block 2 (weeks 13 - 24)
Unit director Dr. Nicola Anderson
Open unit status Not open




School/department School of Cellular and Molecular Medicine
Faculty Faculty of Life Sciences

Description including Unit Aims

This Unit covers the indications for transfusion and transplantation, the process of transfusion, transplantation or tissue engineering including patient testing/cross-matching and adverse effects/complications and their investigation and treatment. It also covers ethics. Students have a unique opportunity to meet some of the country’s leading authorities in transplantation


To explain indications for blood component and product use and alternatives to transfusion. This includes use of blood in emergency situations and provision of blood for specialist patient groups and those with unusual antibodies.

For students to have an in depth knowledge of pre-transfusion testing techniques

To teach the pathophysiology of transfusion reactions, their differential diagnosis, investigation and treatment

For students to have an awareness of reporting regimes for adverse reactions and their benefits

To teach to concept of tissue engineering with current examples

To explain the allocation and transplantation of solid organs, tissues and stem cells including matching, complications (such as organ rejection) and treatment and post transplant monitoring of patients

For students to study a current topic of transplantation in depth

Intended Learning Outcomes

Upon completion of the Unit students should have:

1. An in depth understanding of the use of blood components and products and alternatives to transfusion

2. Explain the provision of blood components for special or difficult patients

3. An in depth understanding of patient testing methods, including being able to interpret antibody identification data

4. A broad knowledge of organ allocation, transplant procedures, and pre transplant testing

5. An in depth understanding of organ rejection mechanisms

should be able to:

6. Diagnose a transfusion reaction and discuss its investigation and patient treatment and know how it should be reported

7. Discuss the pathophysiology of transfusion reactions

8. Explain the concept and benefits of tissue engineering with current examples

9. Discuss the ethical issues in transfusion and transplantation

10. Skills to contribute to a scientific conference such as writing an abstract, giving a talk or preparing a poster

11. Deal with complex or missing data and show decision making in unpredictable situations

12. Demonstrate independent learning ability

13. Synthesise and critically review material from a wide variety of sources

The above are assessed as follows:

Short exam questions 1,2,3,4,5,6,7,8,11

Exam essay questions 1,2,3,4,5,6,7,8,9,11

Assignment 9,10,11,12,13

Teaching Information

Lectures and tutorials NB Contact hours below refers to 15 hours per week over 3 weeks

Assessment Information

One assignment with several tasks relating to conference skills such as giving an oral presentation and preparing a poster and abstract. These tasks may vary each year. (30% of Unit marks)

One 2 ½ hour exam with a section of short answers (approx ½ hour, 20% of Unit marks) and two essays (approx 2hr, 50% of Unit marks).

Students must pass the essay section of the exam with a mark of at least 50%.

Reading and References

Mollinson’s Blood Transfusion in Clinical Medicine 11th edition. Blackwell

Introduction to Organ Transplantation (Ed Hakin). Imperial College Press

Atlas of Clinical Transplantation, Harjula and Hockerstedt. Recallmed

Transplantation 3rd edition (Ed Forsythe). Elsevier

Practical Transfusion Medicine 4th edition (Eds Murphy, Pamphilon, Heddle) Wiley –Blackwell

Postgraduate Haematology 6th edition (Eds Hoffbrand, Catovsky & Tuddenham). Wiley-Blackwell