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Unit information: Intermediate Organic & Biological Chemistry in 2015/16

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Unit name Intermediate Organic & Biological Chemistry
Unit code CHEM20180
Credit points 30
Level of study I/5
Teaching block(s) Teaching Block 4 (weeks 1-24)
Unit director Professor. Wyatt
Open unit status Not open

CHEM10600, CHEM10700, CHEM10800, CHEM10900 (or equivalent mathematics unit as approved by the School).



School/department School of Chemistry
Faculty Faculty of Science

Description including Unit Aims

This unit develops the introduction to inorganic chemistry given in CHEM 10600/700/800 to provide the essential base of organic chemistry required for advanced study at Levels 6 and 7 (Years 3 and 4). It covers the main areas of the subject e.g. the chemistry of carbanions, carbocations and radicals, monofunctional and difunctional carbonyl compounds, aromatic, homocyclic and heterocyclic compounds, amino derivatives and modern aspects of synthesis. Workshops are integral to the unit.

Intended Learning Outcomes

  • Understanding oxidation/reduction reactions and knowledge of functional group interconversions;
  • Knowledge of resonance, acidity, basicity, kinetic vs thermodynamic reactions, and reversibility in reactions;
  • Knowledge of protecting groups for amines and acids;
  • An appreciation of protein structure and the relationship between structure and function;
  • An understanding electrophilic and nucleophilic aromatic substiutions and the factors that influence reactivity;
  • Be able to explain the ways in which solvents can influence reactions;
  • Knowledge of a range of bases of different strengths;
  • Understanding of how bases can be used to make anions and enolates;
  • Be able to draw mechanisms for the reactions of enolates and carbonyl compounds;
  • Knowledge of how to suggest reactions to yield a given synthetic target;
  • An appreciation of the different sorts of reactivity that may be found in organic reactions – stereoselectivity, regioselectivity and chemoselectivity.

Teaching Information

Lectures, workshops (classes of 20 students with two staff members) and masterclasses (interactive seminar sessions of the whole class) and independent study. The Dynamic Laboratory Manual provides important e-learning resource in advance of workshop sessions. Pre-workshop online material will be provided to assist students with the contact workshop.

Assessment Information

Exam: 2 x 2 hours 30 mins.

Reading and References

Essential reading will be from the following books:

Organic Chemistry, 2nd Edition, J Clayden, N. Greeves, S Warren, Oxford University Press, 2012.

Further reading from: Aromatic heterocyclic chemistry, D. T. Davies, Oxford Chemistry Primer 1992; Organic Synthesis, The Disconnection Approach, P. Wyatt and S. Warren, Wiley 2008; Workbook for Organic Synthesis The Disconnection Approach, P. Wyatt and S. Warren, Wiley 2009; Organic Synthesis, C. L. Willis and M. Wills, Oxford Chemistry Primer 1995.