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Unit information: Protein Assemblies and Molecular Machines in 2024/25

Please note: Programme and unit information may change as the relevant academic field develops. We may also make changes to the structure of programmes and assessments to improve the student experience.

Unit name Protein Assemblies and Molecular Machines
Unit code BIOCM0018
Credit points 20
Level of study M/7
Teaching block(s) Teaching Block 2 (weeks 13 - 24)
Unit director Professor. Szczelkun
Open unit status Not open
Units you must take before you take this one (pre-requisite units)

BIOC30002 - Research Training

Units you must take alongside this one (co-requisite units)

BIOCM0015 – Extended Research Project
BIOCM0016 – Science and Society
and either:
BIOCM0017 – Synthetic Biology
or:
BIOCM0019 - Cell Biology of Development and Disease

Units you may not take alongside this one

None

School/department School of Biochemistry
Faculty Faculty of Life Sciences

Unit Information

Lead Contact: Professor Mark Dillingham

Why is this unit important?

This unit will cover the methods used to study the structure and function of molecular machines and will focus on showcasing a number of Bristol’s research strengths in this area.


How does this unit fit into your programme of study?
This unit deepens understanding of topics that are research strengths of the School of Biochemistry, addressing those topics from the perspective of the research scientist. Using a case-based approach, students will learn how to identify and isolate important macromolecular assemblies and how to characterise their structure and cellular function.

Your learning on this unit

An overview of content
Students will cover three main areas:

  • Methods to define the composition of macromolecular complexes.
  • Integrated techniques to analyse the structure of macromolecular complexes.
  • Approaches to studying the functions of macromolecular complexes.
  • How will students, personally, be different as a result of the unit?

After engaging with the unit, students should be able to:

  1. Display an in-depth understanding of how genomic and proteomic data are interpreted in the context of macromolecular complexes.
  2. Evaluate methodologies and approaches used in the study of macromolecular complexes.
  3. Appraise the scientific literature in the field of macromolecular complexes.
  4. Formulate approaches to studying macromolecular complexes.
  5. Develop scientific ideas.
  6. Investigate the scientific process.
  7. Critique and synthesize ideas.
  8. Take an evidence-based approach to solving scientific problems.

Learning Outcomes
Learning on this unit directly addresses components of the Bristol Skills Profile, including:

  • How to express my ideas.
  • How to evaluate the research of others.
  • How to think creatively and innovatively.
  • Communicate confidently and effectively in a range of settings.

How you will learn

Teaching in this unit is normally delivered through a combination of lectures and workshops.
Each topic will be covered over a 2-week period and students will be expected to attend keynote lectures before being set a series of recent research papers to read and synthesize. They will be given opportunities to discuss and consolidate their knowledge through workshops and plenary lectures.

How you will be assessed

Tasks which help you learn and prepare you for summative tasks (formative):

Summative assessments are prepared for through workshop participation and mock exam question sessions.

Tasks which count towards your unit mark (summative):
The components that make up the unit assessment are:

  • Written assessment (60%): a timed assessment consisting of literature comprehension/data handling questions based on prior reading and essays.
  • Coursework (40%) comprising:
    • A submitted PowerPoint file and associated 15-minute oral presentation on the architecture and mechanism of a protein assembly of the student’s choosing (20%).
    • A “News and Views”-type article based on one of a selection of recent high impact papers (20%).

To earn credit for this unit you must normally have made a reasonable attempt at each of the components of the unit assessment. A reasonable attempt requires a student to have undertaken the assessment activity and engaged with its purpose in the academic judgement of the relevant Unit Director, or nominee.


When assessment does not go to plan
Where required, a reassessment normally involves a second attempt at the same form of assessment.

Resources

If this unit has a Resource List, you will normally find a link to it in the Blackboard area for the unit. Sometimes there will be a separate link for each weekly topic.

If you are unable to access a list through Blackboard, you can also find it via the Resource Lists homepage. Search for the list by the unit name or code (e.g. BIOCM0018).

How much time the unit requires
Each credit equates to 10 hours of total student input. For example a 20 credit unit will take you 200 hours of study to complete. Your total learning time is made up of contact time, directed learning tasks, independent learning and assessment activity.

See the University Workload statement relating to this unit for more information.

Assessment
The Board of Examiners will consider all cases where students have failed or not completed the assessments required for credit. The Board considers each student's outcomes across all the units which contribute to each year's programme of study. For appropriate assessments, if you have self-certificated your absence, you will normally be required to complete it the next time it runs (for assessments at the end of TB1 and TB2 this is usually in the next re-assessment period).
The Board of Examiners will take into account any exceptional circumstances and operates within the Regulations and Code of Practice for Taught Programmes.

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