Unit information: The Dynamic Proteome in 2015/16

Unit name	The Dynamic Proteome
Unit code	BIOC30604
Credit points	20
Level of study	H/6
Teaching block(s)	Teaching Block 1 (weeks 1 - 12)
Unit director	Professor. Kelly Moule
Open unit status	Not open
Pre-requisites	BIOC20202 and BIOC20201
Co-requisites	Core Skills (BIOC30603) Advanced Cell Biology (BIOC30601) Cellular Information (BIOC30602) Advanced Options in Biochemistry (BIOC30600)
School/department	School of Biochemistry
Faculty	Faculty of Life Sciences

Description including Unit Aims

Students study advanced topics in protein biochemistry through a series of 30 lectures. These lectures are split into two elements. The first element, Structure and Dynamics of Biomolecules and Systems, covers techniques used to analyse protein structure and dynamics. The second element, Protein Assembly, looks at how proteins are synthesized and how they fold into their unique 3 dimensional shapes. The unit is be assessed by a single 3 hour examination paper.

Aims:

Structure and Dynamics of Biomolecules and Systems

• Protein structure from bonds to macromolecular complexes
• The techniques used to study protein structure
• The study of kinetics in enzymes and chemiosmotic systems
• The techniques to study protein dynamics on femtosecond to hour scales

Protein Assembly

• The synthesis of proteins by the ribosomes
• Sequence to structure relationships and protein folding pathways
• The insertion of peptides and proteins into membranes

Intended Learning Outcomes

• An in-depth knowledge and understanding of the advanced protein biochemistry topics covered in the unit and an ability to keep abreast with recent developments in the field.
• The ability to gather information from the primary scientific literature and to critically evaluate the material and appraise competing theories.
• An understanding of the importance of the study of protein structure and dynamics and an understanding of the experimental tools used to study them.
• An understanding of reaction kinetics and the experimental tools used in the study of kinetics.

Teaching Information

Lectures.

Assessment Information

The unit will be assessed through one 3 hour examination in January. Students will be given a choice of essay titles and will be expected to answer 3 questions.

Reading and References

Reviews and primary articles from the current scientific literature.