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Dr Annela Seddon awarded University Research Fellowship

29 April 2019

Dr Annela Seddon has been awarded a one year University Research Fellowship from the University of Bristol's Institute for Advanced Studies; these awards are made to enable academic staff to carry out a dedicated research project lasting 12 months. Starting in August, 2019, her project will focus on the use of experimental Small Angle X-ray Scattering data, and ab initio modelling of this data to understand liquid-liquid phase separation in biologically relevant systems, such as the clustering of proteins found in 'stress granules', which are a hallmark of neurodegenerative disease.

Above: typical small angle x-ray scattering (SAXS) data collected from the iron storage protein, ferritin. The protein is expressed in the highly thermophilic bacteria, Pyrococcus furiosus.

Above: a bead model of the protein generated from the SAXS data using a Monte Carlo- based simulated annealing method. The hollow core of the protein structure, where iron can be stored as a nanoparticle, can be seen in the model.


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