Dr Alex Greenhough
Current positions
Honorary Senior Lecturer
School of Cellular and Molecular Medicine
Contact
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Research interests
- The role of hypoxia (reduced tissue oxygen levels) in the tumour microenvironment
- Signal transduction pathways in cancer development (particularly Wnt/β-catenin and Hippo-YAP/TAZ)
- The role of autophagy in tissue homeostasis and cancer
- Apoptosis and tumour cell survival
- Cyclooxygenases (COX1 and COX2) and prostaglandins (particularly PGE2)
- Three-dimensional models of normal and cancer tissue (spheroid & organoid culture)
- Post-translational modifications and cancer epigenetics
- Drug resistance & novel targets for cancer therapy
Positions
University of Bristol positions
Honorary Senior Lecturer
School of Cellular and Molecular Medicine
Publications
Recent publications
01/02/2021Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities
Cancers
A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer
Cancer Epidemiology, Biomarkers and Prevention
A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma
LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
Haematologica
BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells
Related people
Professor Ann Williams
Professor of Experimental Oncology
School of Cellular and Molecular Medicine
Professor Karim Malik
Professor of Molecular Oncology
School of Cellular and Molecular Medicine
Miss Tracey Collard
Senior Research Associate
School of Cellular and Molecular Medicine
Dr Marianna Szemes
Lecturer
School of Cellular and Molecular Medicine
Dr Helena Smartt
Medical Statistician / Data Manager
Bristol Medical School (THS)
