Professor Saadeh Suleiman
PhD, DSc, FIACS, FESC, FRSB, FPhysiol
Current positions
Professor of Cardiac Physiology
Bristol Medical School (THS)
Contact
Media contact
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Research interests
Current Research Projects (basic science/translational/clinical):
- Role of cyclic AMP/PKA/Epac signalling in cardioprotection.
- RIPC Clinical Trial: A two-centre randomised controlled trial investigating the effect of remote ischaemic preconditioning on biomarkers of stress and injury-related signalling in patients having isolated coronary artery bypass grafting or aortic valve replacement using cardiopulmonary bypass.
- Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: Propofol cardioplegia for myocardial protection randomised controlled trial: The Prompt2 Study.
- The aged heart and diet: vulnerability to cardiac insults.
- Cardiac remodelling post infarction during postnatal development.
- Effect of inflammation on cardiac remodelling post infarction.
- Hyertension induced cardiac remodelling.
- The cardio-protective efficacy of cardioplegic solution supplemented with Sildenafil in neonatal pig model of cardiopulmonary bypass and cardioplegic arrest.
Projects and supervisions
Research projects
The role of cardiac exchange protein directly activated by cAMP during postnatal development
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
03/02/2016 to 02/02/2019
Role of cyclicAMP/PKA/Epac signalling in cardioprotection
Principal Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/12/2015 to 31/12/2017
Thesis supervisions
Simultaneous Activation of PKA and Epac is Cardioprotective in Neonatal and Adult hearts
Supervisors
Cardiac Survival Signalling, Oxidative Stress & Reperfusion Injury during Postnatal Development
Supervisors
Development and characterisation of a porcine closed chest model of acute myocardial infarction for cells, drugs, and tissue engineering applications.
Supervisors
Post-translational modifications in mitochondrial dynamics
Supervisors
Decellularised Veins as a Scaffold for in situ Vascular Tissue Engineering
Supervisors
Characterisation of post ischaemic cardiac remodelling in rodent and porcine models of cardiac injury
Supervisors
Mechanisms underlying the protective effects of cAMP in cardiac fibrosis
Supervisors
Cardiac Remodelling and Vulnerability to Ischaemia/Reperfusion Injury with Ageing and High-Fat Diet
Supervisors
Publications
0
Recent publications
02/02/2022Cardioprotection of Immature Heart by Simultaneous Activation of PKA and Epac: A Role for the Mitochondrial Permeability Transition Pore
International Journal of Molecular Sciences
Determination of Agrin and Related Proteins Levels as a Function of Age in Human Hearts
Frontiers in Cardiovascular Medicine
Effect of cardioplegic arrest and reperfusion on left and right ventricular proteome/phosphoproteome in patients undergoing surgery for coronary or aortic valve disease
International Journal of Molecular Medicine
Endothelial glycocalyx is damaged in diabetic cardiomyopathy
Diabetologia
Next-Generation and Single-Cell Sequencing Approaches to Study Atherosclerosis and Vascular Inflammation Pathophysiology
Frontiers in Cardiovascular Medicine
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