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My research career has focused on the application of stem cells for the study of neurodevelopment and neurodegeneration, and I now have over 12 years of experience in the culture of multiple types of stem cell and their differentiation into neural cells. My current research focuses on Parkinson’s disease and I am investigating how neuroinflammation, in particular the role of astrocytes contributes to Parkinson’s disease pathology. In brief I am using a hiPSC derived platform to study how astrocytes protect and support neurons but also how chronic disease generates neurotoxic astrocytes.
-The use of patient derived induced Pluripotent Stem Cells (iPSCs) to investigate Parkinsons disease and Alzheimer's disease.
- In particular my work looks at the role astrocytes play in these diseases.
- We generate specific subpopulations of neurons and astrocytes from the iPSCs and we use these to model the diseases.
- In particular I am interested in how astrocytes support neurons and why they can become neurotoxic and how this may pre-empt disease.
University of Bristol positions
Senior Research AssociateSchool of Biochemistry
Journal of Visualized Experiments
Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research
- Chapter in a book
Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes