Dr Katherine Williams
- Fungal Natural Products
- Genome mining
- Heterologous expression
- Biosynthetic Pathways
- Fungal genomics
- Bioactive compounds
Research AssociateSchool of Biological Sciences
Katherine Williams graduated from the School of Biological Sciences, University of Bristol in 2006. She remained in Bristol to study the genetic engineering of PKS-NRPS enzymes and was awarded her PhD in 2010.
She then moved to the School of Chemistry as a Postdoc in the Bristol Polyketide Group, investigating the biosynthesis of fungal metabolites with interesting bioactive properties. Postdocs at the Leibniz Universität Hannover, Germany with Prof Russell Cox, and at Cardiff University with Prof Ruedi Allemann followed.
Katherine now works back in the School of Biological Sciences, Bristol, with Dr Andy Bailey and Prof Chris Willis, on a project developing a high-throughput heterologous production platform for fungal natural product antibiotic discovery.
My research involves the genetic and chemical characterisation of natural products produced by fungi. I utilise techniques such as genome sequencing, bioinformatics, gene knockout and heterologous expression to investigate these compounds.
Frontiers in Fungal Biology
Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi
Microbiology Resource Announcements
Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase
The Biogenetic Origin of the Biologically Active Naematolin of Hypholoma Species Involves an Unusual Sesquiterpene Synthase