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The overall aim of work in this laboratory is to understand central nervous system mechanisms of nociception and pain. The focus is on the physiology, anatomy and neurochemistry of descending control systems that originate in the brainstem and that act to co-ordinate changes in motor, autonomic and sensory functions, including pain. These systems underlie the co-ordinated patterns of change in behaviour, nociceptive responsiveness and autonomic outflow that occur: (i) during fever, as part of a sickness response (ii) in different behavioural states, such as fear and anxiety, (iii) in certain pathophysiological conditions, such as stress related disorders and chronic pain.
A better understanding of the neural basis of pain will help develop new strategies for the treatment of chronic pain, such as that which accompanies arthritis.
University of Bristol positions
Professor of Systems NeuroscienceSchool of Physiology, Pharmacology & Neuroscience
Dynamic contributions of prefrontal-midbrain-spinal cord networks to the development and maintenance of chronic neuropathic pain.
01/01/2017 to 31/12/2019
Contributions of prefrontal-midbrain-spinal cord network dynamics to the development and maintenance of chronic neuropathic pain
Managing organisational unit
01/12/2016 to 30/11/2019
01/03/2009 to 01/09/2013
LOCAL TRANSLATION OF MRNA IN PRIMARY AFFERENT FIBRES: A NOVEL MECHANISM FOR THE CONTROL OF PAIN AND ITCH
26/05/2009 to 26/08/2012
The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation
Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats
Cerebellum and Ataxias
- Accepted/In press
- E-pub ahead of print