She is the author of several widely-used software packages including database and transaction libraries and the 4.4BSD log-structured file system. Dr. Seltzer was a co-founder and CTO of Sleepycat Software, the makers of Berkeley DB and is now an Architect for Oracle Corporation. She serves on the Computer Science and Telecommunications Board (CSTB) of the (US) National Academies and the Defense Advanced Research Projects Agency (DARPA) Information Science and Technology (ISAT) Study Group. She is a past President of the USENIX Assocation and served as the USENIX representative to the Computing Research Association Board of Directors and on the Computing Community Consortium. She is a Sloan Foundation Fellow in Computer Science, an ACM Fellow, a Bunting Fellow, and was the recipient of the 1996 Radcliffe Junior Faculty Fellowship. She is recognized as an outstanding teacher and mentor, having received the Phi Beta Kappa teaching award in 1996, the Abrahmson Teaching Award in 1999, the Capers and Marion McDonald Award for Excellence in Mentoring and Advising in 2010, and the CRA-E Undergraduate Research Mentoring Award in 2017.

Professor Seltzer received an A.B. degree in A