Properties of aerosol used in the delivery of drugs to the lungs
We are exploring in this project the coupling of mass and heat transfer that occurs during the rapid evaporation or growth of aerosol. Measurements are providing direct in situ information on the evolving size and composition of particles with high time resolution. New work is examining the hygroscopic behaviour of typical drug excipients and surfactants used in pulmonary aerosol delivery and the kinetics of their size response.
For examples, see:
A.E. Haddrell, J.F. Davies, R.E.H. Miles, J.P. Reid, L.A. Dailey and D. Murnane, 'Dynamics of aerosol size during inhalation: Hygroscopic growth of commercial nebulizer formulations', International Journal of Pharmaceutics 463 (2014) 50-61 - pdf
A.E. Haddrell, G. Hargreaves, J.F. Davies and J.P. Reid, 'Control over Hygroscopic Growth of Saline Aqueous Aerosol Using Pluronic Polymer Additives', International Journal of Pharmaceutics 443 (2013) 183-192 - pdf