Novel molecular designs unlock therapeutic potential of nicotine receptors
Researchers from the University of Bristol, have been examining the chemistry and pharmacology of one of the key smoking cessation drugs, cytisine (Tabex). Using computational simulation methods developed with the aid of Bristol’s high performance computing facilities at ACRC, the researchers have unpacked how the modified chemical structure determines the biological profiles of these new cytisine variants. With further research, this work has the potential to produce a new smoking cessation therapy based on cytisine that, may lead to higher and more sustained quit rates.
Lung cancer drug resistance explained by computer simulations
Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib - an anticancer drug used to treat types of lung cancer.
3D pentagons and metallic glasses
Researchers from the University of Bristol have used state-of-the-art computer simulation to test a theory from the 1950s that when atoms organise themselves into 3D pentagons they suppress crystallisation.
Study shows how Ebola evolved during the outbreak in West Africa
University of Bristol researchers used Bristol’s Supercomputer, BlueCrystal, to analyse raw data on the Ebola virus in 179 patient blood samples to determine the precise genetic make-up of the virus in each case. This research informed public health policy in key areas such as diagnostic testing, vaccine deployment and experimental treatment options.
BlueCrystal used to shed light on the origins of the chloroplast
A new study, led by the University of Bristol, has shed new light on the origin, timing and habitat in which the chloroplast first evolved.
BlueCrystal used to simulate the climate of Game of Thrones
Scientists from the Universities of Bristol, Cardiff, and Southampton have used a Climate Model to simulate and explore the climate of the world of Game of Thrones.
BlueCrystal used to compare how bat and human cells respond to viruses
With the assistance of Bristol’s High Performance Computing team, the researchers used the University's supercomputer, Blue Crystal, to identify about six thousand genes and proteins made by the bats and examine how these genes and proteins changed in response to infection by the Hendra virus. A similar analysis was also done on the human cells.