Experiment | Special Features | Related Course | Points |
---|---|---|---|
Evans Alkylation | Use of LDA, enantio- and diastereo-selectivities | TCG | 4 |
Enzyme Resolution | Enantioselectivity. Enzymes in organic synthesis | RJC | 2 |
Horner-Wittig | P stabilised carbanion. Stereospecificity, Pure E or Z alkenes | CLW | 4 |
Sharpless Asymmetric Dihydroxylation | Chiral ligand, catalysis, product value, effect of recrystallisation on ee | TCG | 3 |
Structure Elucidation of a commercial pharmaceutical | Real life interest, Using School of Chemistry analytical services(elemental, NMR, MS) | --- | 1 |
Aldol Coupling Stereochemistry | Use of nOe to determine relative stereochem. Simple protecting group chemistry | RJC | 2 |
Nickel Catalysed Coupling | Isotope labelling. Catalytic coupling. Sublimation as a purification. | GCL-J | 3 |