Skip to main content

Unit information: Haemopoietic Stem Cell Transplantation in 2018/19

Please note: It is possible that the information shown for future academic years may change due to developments in the relevant academic field. Optional unit availability varies depending on both staffing and student choice.

Unit name Haemopoietic Stem Cell Transplantation
Unit code PANM33006
Credit points 20
Level of study H/6
Teaching block(s) Teaching Block 4 (weeks 1-24)
Unit director Professor. Steward
Open unit status Not open
Pre-requisites

PANM22041 Infection and Immunity

PANM22042 Cellular & Molecular Pathology

MOLG22100 Recombinant DNA Technology

MOLG22200 Gene Expression and Rearrangement.

FMVS20001 Biomedical Research, Employability and Enterprise Skills

Co-requisites

3 from level 6/H lecture units and Research Skills unit.

School/department School of Cellular and Molecular Medicine
Faculty Faculty of Biomedical Sciences

Description

The most tangible evidence of advances in genetic, protein and cellular sciences is seen in haemopoietic stem cell transplantation. From early attempts at bone marrow transplantation, this has broadened to include the use of stem cells mobilised by growth factors from the donor's marrow into their bloodstream, cord blood and mesenchymal stem cells. Genetic advances have revolutionised the speed and accuracy of tissue typing, the assessment of engraftment and graft rejection, accurate quantitation of malignant cells and early detection of viral infections. Advances in antibody technology now allow the accurate selection of stem cells and of cells capable of fighting specific viral infections. This topic examines the biology of stem cells and the technology behind these advances, focussing particularly on how successful research in this School has been transferred from the laboratory to clinical application, bringing major benefits to clinical care. Lectures in weeks 13-16.

Aims:

To bilaterally teach scientists how basic scientific innovation can be translated rapidly to improve clinical care, and intercalating medical students the importance of collaborative research with scientists in areas which can readily translate. The Bone Marrow Transplant Unit at Bristol Royal Hospital for Children and members of the School of Cellular and Molecular Medicine have a wide-ranging and internationally renowned expertise in translational science. Once students have been taught the basics of haemopoietic stem cell transplantation, this is used to enthuse them in the importance of translational science to best quality medical care.

Intended learning outcomes

Knowledge and Understanding of haemopoietic stem cell transplantation, its history and its therapeutic potential. Knowledge of the scientific literature pertaining to stem cell transplantation and an ability to evaluate this literature critically.

Teaching details

Lectures, Data Handling Session

Where possible the unit will include a visit to the NHS - Blood and Transplant facilities in Filton.

Independent study: Students are expected to study the recommended literature.

Assessment Details

Summative 3 hour written exam, to include 3 essays chose from 6.

Reading and References

Reviews and primary articles from the current scientific literature.

Feedback