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Unit information: Cancer Mechanisms and Therapeutics in 2018/19

Please note: It is possible that the information shown for future academic years may change due to developments in the relevant academic field. Optional unit availability varies depending on both staffing and student choice.

Unit name Cancer Mechanisms and Therapeutics
Unit code PANM33004
Credit points 20
Level of study H/6
Teaching block(s) Teaching Block 4 (weeks 1-24)
Unit director Dr. Abderrahmane Kaidi
Open unit status Not open
Pre-requisites

PANM22041 Infection and Immunity

PANM22042 Cellular & Molecular Pathology

MOLG22100 Recombinant DNA Technology

MOLG22200 Gene Expression and Rearrangement.

FMVS20001 Biomedical Research, Employability and Enterprise Skills

Co-requisites

3 level 6/H lecture units and Research Skills unit.

School/department School of Cellular and Molecular Medicine
Faculty Faculty of Biomedical Sciences

Description

This unit covers cellular and molecular changes that result in common cancers such as breast and colon including genetics of colorectal (FAP and HNPCC) and breast cancer (BRCA1 and BRCA2). Importance of tumour microenvironment, inflammation and NFkB in carcinogenesis. DNA repair pathways, genomic stability and breast cancer will be covered. Regulation of the cell cycle by the tumour suppressor genes, TGFbeta, Rb, p53, and why loss of function represents the most common event in human cancer. Normal apoptosis pathways, deregulation of apoptotic signalling in carcinogenesis and its role in the development of drug resistance. This unit will also include a brief review of the epidemiology of cancer and current approaches for both cancer prevention (NSAIDs) and the exploitation of targets, described above, for novel chemopreventive and therapeutic approaches. Data handling/essay writing tutorial.

Aims:

the aims are to increase our understanding of how cancer develop and in particular which key genes and growth signalling pathways become defective and lead to the development of common adult sporadic and hereditary cancers. A further aim is to show how knowledge of these defective signalling pathways can lead to novel measures to prevent cancer and new treatments for the early detection and cure of cancer.

Intended learning outcomes

Knowledge and understanding of which key genes and signalling pathways become deregulated during multistage carcinogenesis and give rise to major common adult cancers such as breast and bowel cancer. Knowledge and understanding of how the identification of deregulated signalling pathways and tumours environment (whether inherited or acquired) can lead to the development of new chemopreventive and therapeutic approaches for cancer.

Knowledge of the scientific literature pertaining to cancer mechanisms and therapeutics and an ability to evaluate this literature critically.

Teaching details

Lectures, Data Handling Session

Independent study: Students are expected to study the recommended literature.

Assessment Details

Summative 3 hour written exam, to include 3 essays chose from 6.

Reading and References

Reviews and primary articles from the current scientific literature.

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