Studying the interactions between nutrition and IGFs on chronic health disorders across the lifecourse

Lifecourse epidemiology is the study of how exposures throughout life impact upon the development of major chronic health disorders.

Nutrition is one of the most important exposures throughout life and the IGF-insulin system mediates many of its consequences on tissue functions. Using the rich resource of contemporary and historical cohorts investigated by Richard MartinDavid GunnellYoav Ben-ShlomoGeorge Davey Smith and Jenny Donovan, we have investigated the nutritional determinants of the IGF system, its consequences on childhood development and on the subsequent development of cancers, cardiovascular disease and obesity in later life.

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