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Cortisol effects on locus coeruleus activity (CELCA) - Version 2.0

14 October 2019

This is a research project looking at how manipulating certain stress hormones and neurotransmitters affects a part of the brain called the locus coeruleus.

What does it involve?

  • Picking up tablet medication the day before testing and taking this medication yourself at home.
  • Providing a urine sample the day before testing to allow for pregnancy and drug testing.
  • Attending testing which will involve sitting in front of a computer screen and responding to certain auditory tones as quickly as possible.
  • Testing will take about 45 minutes.
  • After testing there will be a break of at least 10 days after which you will be asked to repeat the above procedure but with a different tablet medication.
  • This will occur 4 times in total with 4 different tablet medications.
  • There are minimal side effects associated with these treatments. They are all medications that are commonly prescribed.
 
What are the benefits to me?
  • There are no direct benefits however we will reimburse you £100 for your time spent on the whole study period. This is to compensate you for the inconvenience of missing work or university.
  • You may also receive up to £80 reward if you perform well in the 4 auditory tasks.

You are eligible if you meet ALL of the following criteria:

  • Male or female, aged 18-64
  • Not pregnant or breastfeeding
  • Fit and healthy with no medical problems
  • Not taking steroid or hormonal medications nor illegal substances
  • Non-smoker
  • Fluent in English
  • No problems with eye sight (can read large text without glasses or with contact lenses)
  • No history or diagnosis of immunosuppressive disorders, blood disorders or psychiatric illness.
  • BMI in the 19-29 range

Further information

If you are interested in taking part or finding out more
Please contact Laura Cole (PhD Student in Neuroscience)

CELCA-study@bristol.ac.uk

Tel: 07784763527

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