Current trials

Trial acronymTrial title

A multi-centered randomised trial to compare 1 stage with 2 stage revision surgery for prosthetic hip joint infection

ProtecT trial  Evaluating the effectiveness of treatments for clinically localised prostate cancer
RADAR trial
Reducing Alzheimer's Disease through Angiotensin TaRgetting
ROMIO trial Randomised Oesphagectomy: Minimally Invasive or Open surgery
UPSTREAM Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment of Methods (UPSTREAM) for diagnosis and management of bladder outlet obstruction in men
CAP Cluster randomised trial of PSA testing for Prostate cancer
NAPSACC A feasibility cluster randomised controlled trial in child care settings to increase physical activity and healthy eating in 2-4 year olds
MAGENTA What is the best model for delivering specialist NHS Chronic Fatigue Syndrome or Myalgic Encephalopathy  

STAR: Chronic pain after total knee replacement: better post-operative prevention and management


An RCT investigating the relative clinicaL and cost-effectiveness of the FITNET-NHS (Fatigue in Teenagers on the interNET in the NHS) intervention compared with Activity Management, amont children with Chronic Syndrome or Myalgic Encephalomyelitis (CFS/ME) who do not hae a local NHS specialist CFS/ME service.


INTERACT is a 6-year research programme to design and evaluate integrated therapist and online CBT for depression in primary care


WISE: A cluster randomised controlled trial evaluating an intervention to improve the mental health support and training available to secondary school teachers


REPROVIDE: (Reaching Everyone Programme of Research On Violence in diverse Domestic Environments).  This research plans to improve how healthcare professionals respond to all adult patients who experience or perpetrate DVA and to their children.  The programme consists of two trials, one testing a primary care based intervention to improve the response to male survivors and children exposed to DVA, the other testing a group intervention for perpetrators of DVA.


ADEPT: Guided Self-Help for Depression in adults with Autism: A feasibility RCT


BEE: (Best Emollient for Eczema) is a research study that is trying to improve the treatment of childhood eczema by providing information about which emollients (moisturisers) are most acceptable and effective.

Prepare for Kidney Care

The Prepare Multi-Morbid Older People for End-Stage Kidney Disease Trial.  This study is a two-arm superiority, parallel group, non-blinded, individual-level, pragmatic RCT in multi-morbid, frail, older people with advanced chronic kidney Disease (CKD), comparing the Quality Adjusted Life years (QUALY) gained over three years after preparing for conservative care versus preparing for dialysis.

Action 3:30

Action 3:30: A cluster randomised feasiblity trial evaluating teaching assistant led, extra curricular physical activity intervention for 8 to 10 year olds.


Our research aims to establish the effectiveness of haemodialysis versus haemodiafiltration in the treatment of kidney disease.


TEST: (Trial of Eczema allergy Screening Tests) is a feasibility study to help determine if routine allergy tests can help treatment of children with eczema.


IMPPP: Improving Medicines use in People with Polypharmacy in Primary Care.


EPIToPE: Evaluationg the Population Impact of Hepatitis C Direct Acting Antiviral Treatment as Prevention for People Who Inject Drugs.

CHICO  The CHICO study is aiming to improve the treatment and care of children attending GP practices with coughs and acute respiratory tract infection (RTI).

TRIUMPH: (TReating Urinary symptons in Men in Primary Healthcare) is a study of treating men who have urinary problems (Lower Urinary Tract Symptoms, LUTS that have a significant impact on their daily lives.

REST  Immediate Oral, immediate topical or delayed oral antibiotics for acute otitis media with discharge: The Runny Ear STudy (REST)
CHIEF-PD  CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease.  
PLAN-A  PLAN-A: A cluster randomised controlled trial of a Peer-Led physical Activity iNtervention for Adolescent girls.  
NAPSAAC UK A multicentre cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of an environmental nutrition and physical activity intervention in nurseries (Nutrition and Physical Activity Self Assessment for Child Care - NAP SACC UK)
PRIME Parkinson  Proactive and Integrated Management and Empowerment in Parkinson’s Disease
PURSUIT PURSUIT: Proper Understanding of Recurrent Stress Urinary Incontinence Treatment in women: a randomised controlled trial of endoscopic and surgical treatment.

The PURSUIT study is a NIHR-funded two-arm trial randomising women with recurrent stress urinary incontinence (SUI) to endoscopic urethral bulking injections or a surgical operation.  There is currently no good evidence about which is the most effective treatment for recurrent SUI.  The PURSUIT study will help us to identify which treatment is better for improving symptoms and quality of life for women with this condition.  We plan to recruit 250 women from 20 NHS centres throughout the UK.  The study will run for 6 years, with 2 years of recruitment and 3 years of follow-up.

Care Leavers  Promoting good health in Care Leavers through training for Personal Advisors
STRATA  SerTRaline for AnxieTy in adults with a diagnosis of Autism 
Edit this page