Dr Chrissy Hammond

Lab Overview

Our group uses zebrafish as an animal model to gain insight into joint and skeletal diseases.

Research Questions

Our main research questions are as follows:

  • What are the first (and likely most treatable) signs of disease in osteoarthritis?
  • How do human disease genes influence the cells of the skeletal system to cause pathology?
  • How do cells sense and integrate information about mechanical loading and genetic information?
  • Can we use our knowledge of disease genetics to identify new drug targets for osteoporosis, fracture repair and osteoarthritis?
  • How do we regulate the skeletal system during development and ageing?
  • Can we develop new computational tools to improve our analysis?

 

Techniques

We use a lot of in vivo imaging to visualise the musculoskeletal system, this includes fluorescent confocal, multiphoton and lightsheet microscopy, micro-Computed tomography and synchtron powered tomography. We use genome editing to test how genes associated with human disease act on the cells of the skeletal system and we use a wide range of other techniques (behavioural tests, bone loading test and computational modelling) to understand how the skeletal system performs through life in health and disease

Impact

Our lab are very active in public engagement and have run week-long sessions at the region science centre We the Curious (https://www.wethecurious.org/event/fish-space)

We engage with local artists e.g. through Creative Reactions (https://pintofscience.co.uk/event/creative-reactions)

I am on the Science review committee for the UK Bigbang fair, the largest national science fair for school students held at the NEC each year (https://www.thebigbangfair.co.uk/)

My group and I regularly run schools events, give public talks and help out at festivals.

Selected Publications

View complete publications list in the University of Bristol publications system.

Funding

Versus Arthritis Senior Fellowship: An integrated approach to joint disease through the lifespan(2018-2023)

Arthritis Research UK project grant: Spinal disc degeneration (2016-2020)

STFC project grant: Fish in space (2018-2019)

Group

  • Dr Erika Kague
  • Dr Dylan Bergen
  • Dr Elis Newham
  • Lizzie Lawrence
  • Lucy McGowan
  • Abdelwahab Kawafi
  • Jessye Aggleton
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