Dr Chrissy Hammond
Our group uses zebrafish as an animal model to gain insight into joint and skeletal diseases.
Our main research questions are as follows:
- What are the first (and likely most treatable) signs of disease in osteoarthritis?
- How do human disease genes influence the cells of the skeletal system to cause pathology?
- How do cells sense and integrate information about mechanical loading and genetic information?
- Can we use our knowledge of disease genetics to identify new drug targets for osteoporosis, fracture repair and osteoarthritis?
- How do we regulate the skeletal system during development and ageing?
- Can we develop new computational tools to improve our analysis?
We use a lot of in vivo imaging to visualise the musculoskeletal system, this includes fluorescent confocal, multiphoton and lightsheet microscopy, micro-Computed tomography and synchtron powered tomography. We use genome editing to test how genes associated with human disease act on the cells of the skeletal system and we use a wide range of other techniques (behavioural tests, bone loading test and computational modelling) to understand how the skeletal system performs through life in health and disease
Our lab are very active in public engagement and have run week-long sessions at the region science centre We the Curious (https://www.wethecurious.org/event/fish-space)
We engage with local artists e.g. through Creative Reactions (https://pintofscience.co.uk/event/creative-reactions)
I am on the Science review committee for the UK Bigbang fair, the largest national science fair for school students held at the NEC each year (https://www.thebigbangfair.co.uk/)
My group and I regularly run schools events, give public talks and help out at festivals.
Bergen DJM, Kague E, Hammond CL. (2019). Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds.Front Endocrinol (Lausanne). 10:6. doi: 10.3389/fendo.2019.00006. https://www.ncbi.nlm.nih.gov/pubmed/30761080
Kague, E., Lawrence, E., Cross, S., Martin, L. Hughes, SM. Hammond, CL* and Hinits Y* 2019, Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish FASEB Journal (In press) *Equal contribution https://research-information.bris.ac.uk/pure/files/190706029/scx_paper_small_FV.pdf
Lawrence EA, Kague E, Aggleton JA, Harniman RL, Roddy KA, Hammond CL (2018). The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function which lead to early onset osteoarthritis. Phil Trans R Soc B. 373(1759). pii: 20170335. doi: 10.1098/rstb.2017.0335 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158203/
Brunt LH, Kague E, Begg K Cross S, Hammond CL. 2017 Wnt Signalling Controls the Response to Mechanical Loading during Zebrafish Joint Development. Development doi: 10.1242/dev.153528. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560048/
Brunt LH, Norton JL, Bright JA, Rayfield EJ, Hammond CL. 2015. Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development. J Biomech;48(12):3112-22 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601018/
View complete publications list in the University of Bristol publications system.
Versus Arthritis Senior Fellowship: An integrated approach to joint disease through the lifespan(2018-2023)
Arthritis Research UK project grant: Spinal disc degeneration (2016-2020)
STFC project grant: Fish in space (2018-2019)
- Dr Erika Kague
- Dr Dylan Bergen
- Dr Elis Newham
- Lizzie Lawrence
- Lucy McGowan
- Abdelwahab Kawafi
- Jessye Aggleton