£1.1M for study into how ‘acetylcholine’ influences brain network activity15 November 2013A £1.1 million grant to understand how one of the brain’s key neurotransmitters called ‘acetylcholine’ influences brain activity has been awarded to University of Bristol researchers. The Wellcome Trust award will help scientists understand more precisely how the release of acetylcholine is changing brain cell activity to influence memory and cognition.
Special issue of Neuropharmacology to celebrate seminal discovery.15 November 2013In 1983, Graham Collingridge and colleagues made the seminal discovery that long term potentiation (LTP) in area CA1 of the hippocampus was mediated by the NMDA subtype of glutamate receptor. n his honour, Neuropharmacology have published a Special Issue of the journal entitled ‘Glutamate receptor-dependent synaptic plasticity’, edited by David Lodge, Zafar Bashir and David Jane.In his honour, Neuropharmacology have published a Special Issue of the journal entitled ‘Glutamate receptor-dependent synaptic plasticity’, edited by David Lodge, Zafar Bashir and David Jane.
Study finds link between commonly prescribed statin and memory impairment27 September 2013New research that looked at whether two commonly prescribed statin medicines, used to lower low-density lipoprotein (LDL) or ‘bad cholesterol’ levels in the blood, can adversely affect cognitive function has found that one of the drugs tested caused memory impairment in rats.
Researchers solve 20-year puzzle of how heart regulates its beat6 June 2013A 20-year puzzle as to how the heart regulates contraction appears to have been solved by researchers from the University of Bristol. The findings, published in the journal Biophysics, paves the way to improving our understanding of what goes wrong when the heart fails.
Scientists identify brain’s ‘molecular memory switch’28 March 2013Scientists have identified a key molecule responsible for triggering the chemical processes in our brain linked to our formation of memories. The findings, published in the journal Frontiers in Neural Circuits, reveal a new target for therapeutic interventions to reverse the devastating effects of memory loss.
Calcium is initial trigger for immune response to healing18 February 2013For the first time scientists studying the cellular processes underlying the body’s response to healing have revealed how a flash of calcium is the very first step in repairing damaged tissue. The findings could lead to new therapies that speed up the healing process following injury or surgery.
Culprit identified in obesity-associated high blood pressure2 February 2013Obesity and its related conditions such as type 2 diabetes, cardiovascular disease and stroke are among the most challenging of today’s healthcare concerns. Together, they constitute the biggest killer in western society. New findings, published by Dr Nina Balthasar in the journal Cell, have identified a target that could hold the key to developing safe therapies to treat obesity and its associated condition.
Researchers identify new target for common heart condition9 January 2013Researchers have found new evidence that metabolic stress can increase the onset of atrial arrhythmias, such as atrial fibrillation (AF), a common heart condition that causes an irregular and often abnormally fast heart rate. The findings may pave the way for the development of new therapies for the condition which can be expected to affect almost one in four of the UK population at some point in their lifetime.