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Professor Graeme Henderson

Professor Graeme Henderson

Professor Graeme Henderson
B.Sc.(Glas.), MA, Ph.D.(Aberd.), Hon FBPhS, FRSB

Professor of Pharmacology

Area of research

Opioid Drug Action

Office G24b
Biomedical Sciences Building,
University Walk, Bristol BS8 1TD
(See a map)

Tel. +44 (0) 117 331 1431

Research summary

Our research is aimed at understanding the lethality of opioid drugs such as heroin, methadone and fentanyl in opioid overdose and how their lethality (through depression of respiration) can be enhanced by other drugs such as alcohol and gabapentinoids.

Prolonged use of opioids results in the development of tolerance whereby the effect of the drug (euphoria or respiratory depression) is reduced and more drug must be taken to induce the original level of effect. We have demonstrated that the mechanisms underlying tolerance may be different for different opioids and that alcohol and gabapentinoids lower heroin but not methadone tolerance.

We ...

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Selected publications

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Recent publications

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View complete publications list in the University of Bristol publications system

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