Genetic Epidemiology

Course dates

18 - 22 June 2018.

Course duration

5 days (approximately 28 hours teaching with a combination of lectures and practicals).
Registration will start at 9am on the first day, the course will finish by 5pm on the final day.

Course tutors

Dr Sarah LewisDr Lavinia Paternoster (course organisers) and others.

Course aims 

Participants will gain a grounding in a wide range of cutting-edge genetic epidemiological methods for complex traits.

Course objectives

By the end of the course participants should be able to:

  • understand the major sources of genetic variation in the genome;
  • infer the genetic architecture of a trait using results from twin studies and whole genome approaches;
  • design and analyse a basic genome-wide association study using appropriate software;
  • consider population structure and its application to genetic association studies;
  • work with a range of genetic data types: e.g. genotyped, imputed, sequenced, polygenic risk scores;
  • utilise online bioinformatic resources to explore the functional properties of genetic variation;
  • interpret results from studies of molecular gene regulation (e.g. expression and methylation);
  • utilise results from genetic association studies to investigate genetic correlation and causality in epidemiological associations.  

Who the course is intended for

  • Epidemiologists.
  • Statisticians.
  • Molecular Biologists.
  • Clinicians.
  • Psychologists. 

This course will require students to use analytical software in a command-line Linux environment. We will include all instructions, but do recommend that you have some experience of this computer environment before the course.

Course outline

Introduction to genetics:
- molecular structure;
- variation & population structure. 

Introduction to data types & formats:  
- genotyping;  
- imputed genetic data;  
- sequence data;  
- other ‘omics (e.g. expression, methylation);  
- use of summary statistics.     

Heritability & genetic architecture of complex traits:
- twin studies;  
- whole genome approaches;

Genetic association of complex traits:
- statistical tests for association;
- genome-wide association study (GWAS) analysis;
- study design, confounding, statistical power;
- construction & use of polygenic risk scores;
- next Generation Sequence analysis;
- bioinformatic follow-up of results to explore functional mechanisms.

Related study designs:
- other ‘omics (e.g. expression, methylation);
- mendelian randomization for causal inference in Epidemiology;
- recall by genotype studies.

Please note: This course will be held in a computer lab, you will not need to bring a laptop.

Booking

Make a booking

Places available.

This course provided a very good overview of genetic epidemiology. Being a very complex subject in itself, it was great in that we went from the very basics to more complex topics.

Course feedback, April 2017

Course fee

£1,100

More information on course fees, fee waivers and reduced prices.

Course venue

Bristol Medical School
Canynge Hall
39 Whatley Road
Bristol
BS8 2PS
United Kingdom

Map and directions

Course refreshments

We provide morning and afternoon refreshment breaks, including tea and coffee, biscuits and fresh fruit.

If you have specific dietary needs we ask that you let us know in advance.

Lunch is not included. There are a range of local cafes and supermarkets nearby for students to purchase lunch. 

Accommodation

Information about accommodation in the area.

Contacts

For further information please email short-course@bristol.ac.uk.

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