The release of Ca2+ from intracellular stores is of fundamental importance in cell biology, playing a key role in a wide variety of cellular functions including cardiac and skeletal muscle contraction, fertilisation, cell division and neurotransmitter release.
We study the function of intracellularly-located ion-channels involved in the regulation of intracellular Ca2+-release. Ion-channels that we are particularly focusing on include ryanodine receptors (RyR), TRIC-A and TRIC-B channels, nicotinic acid adenine dinucleotide receptors (NAADR), Two-Pore channels (TPCs) and cyclic ADP-ribose receptors (cADPR).
Ryanodine receptors (RyR) are an important class of intracellular Ca2+-release channel in cardiac muscle. Cardiac muscle contraction requires release of intracellular Ca2+. Impairments to this release process can be fatal as in inherited arrhythmic diseases and heart failure.