Understanding mechanisms

Work package 3: Mechanisms

Leads Prof Julian Higgins, Prof Jeff Holly, Prof Nic Timpson

Understanding mechanisms which are potentially amenable to intervention is the core focus of Work package 3.  Two parallel and complimentary strands of research are used:  The first is systematic reviews of mechanistic studies, based on cancer-causing exposures which will be identified in Work package 1, and the second is using studies to recall population sub-groups, or their bio-samples, according to genotype for prediction of phenotype.

Future work will involve establishing and optimising laboratory assays for initial recall studies; the continuation of an investigation of the biological impact of vitamin D and glucose levels on intermediate endpoints.

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