David Telling Grant11 December 2017Enhanced PPAR-delta expression in patients with periodontitis promotes the inflammatory and pro-atherosclerotic properties of monocytes/macrophages
The most common cause of heart attacks is atherosclerosis.
Major funding boost for internationally-recognised healthcare research centres11 December 2017Three interdisciplinary research consortia, including the University of Bristol's SPHERE project, have been allocated more than £11 million to continue healthcare sensing systems research that is revolutionising how we identify and respond to outbreaks of infectious diseases, diagnose and manage lung diseases, and recognise and solve emerging health and wellbeing issues in the home environment.
Research reveals how cells rebuild after division4 December 2017University of Bristol research has revealed how cells rebuild their nucleus and organise their genome when they divide – a discovery which could have major implications for understanding cancer and degeneration.
Biology and chemistry combine to generate new antibiotics28 November 2017Combining the innovations of synthetic biology with biology and chemistry, a team of scientists at the University of Bristol have generated a brand-new platform that will allow the production of desperately needed brand-new antibiotics.
Breastfed babies are less likely to have eczema as teenagers, study shows17 November 2017Babies whose mothers had received support to breastfeed exclusively for a sustained period from birth have a 54 per cent lower risk of eczema at the age of 16, a new study led by researchers from King's College London, Harvard University, University of Bristol and McGill University shows.
Bristol wins grant to tackle antibacterial drug resistance in Thailand16 November 2017The University of Bristol has been awarded a grant through the Antimicrobial Resistance (AMR) cross-research council initiative, in partnership with the Department of Health, to lead an inter-disciplinary research project to tackle the growing threat of antibacterial drug resistance (ABR) in Thailand.
Antibiotic Discovery in the Abyss15 November 2017Combining the innovations of synthetic biology with robotic environmental sampling, a team of University of Bristol researchers are travelling to some of the most ‘extreme’ environments on Earth, including Atlantic depths of 4.5km, to find new leads which could help in the global fight against antimicrobial resistance.
Primary care is key to optimising value in healthcare14 November 2017Balancing improvements in health against the cost of such improvements in primary care is vital to achieve a cost-effective and efficient healthcare system, finds a new report by University of Bristol researchers and published in the BMJ.
New international consortium to accelerate drug discovery in kidney diseases8 November 2017A new consortium to accelerate the discovery of novel drugs to treat kidney diseases was announced on Monday, 6 November 2017. The NEPLEX (nephron on a chip with cellular and extracellular matrix complexity) consortium, comprising leading academic institutions including the Universities of Bristol and Cambridge, and Evotec AG, will combine key technologies to develop and build a novel drug discovery device ("Nephron-on-a-Chip").
Academy of Medical Sciences grant to Dr Sofia Theodoropoulou2 November 2017Age-related macular degeneration (AMD) is a leading cause of irreversible blindness. Current treatments are available only for the very late stages of the wet form of AMD (caused by the aberrant growth of new vessels-angiogenesis) and only improve vision in 30% of those patients.
Key discoveries offer significant hope of reversing antibiotic resistance30 October 2017Two recent studies led by the University of Bristol provide significant new hope in the fight against antibiotic resistance. By identifying what makes some bacteria resistant to the most commonly prescribed antibiotics, and how this can be reversed, the findings have demonstrated potentially life-saving consequences and could help reverse the tide of antibiotic resistance.
Interventions for reducing hepatitis C infection in people who inject drugs26 September 2017The first global review to quantify the impact of needle syringe programmes (NSP) and opioid substitution treatment (OST) in reducing the risk of becoming infected with the hepatitis C virus is published in Cochrane Library Drug and Alcohol Review Group and the journal Addiction. The study, has implications for millions of people who are 'at risk' from infection.
How are antimicrobials used around the world in food-producing animals?4 September 2017A new study led by academics at the Bristol Veterinary School has reviewed the literature on the use of antimicrobials (AM) in livestock practice together with the views of stakeholders. The study found that although there are some barriers to change, there is a clear awareness of the issue among the livestock sectors and a willingness to modify AM use.
WUN Strategic Research Workshop1 August 2017The World Universities Network Global Africa Group launched its inaugural Strategic Research Workshop, hosted by the University of Ghana in a two-day event that brought together over sixty researchers from twelve WUN partner universities and ten other universities from four continents.
Transforming UK Translation commitments27 July 2017The Academy of Medical Sciences, Royal Academy of Engineering, Royal Society, and the Wellcome Trust, have outlined a series of commitments to ensure that translation is recognised and celebrated as an integral part of academic research.
How can diagnostics deliver a more effective use of antibiotics in animals?12 July 2017Are there better ways to diagnose animals in need of antibiotics on livestock farms? How will farmers and veterinarians use novel diagnostics in the fight against animal disease? These are some questions a consortium of seven academics – including two veterinarians from the University of Bristol's School of Veterinary Sciences - will address thanks to a £1.75 million grant to understand how better diagnostics can encourage responsible antibiotic use in animals.
New trial for prosthetic hip joint infection28 June 2017The first ever randomised trial to investigate why some patients develop infections after their hip or knee replacement surgery, and which type of surgical revision treatment is best is being run by the University of Bristol and members of the public are being asked to consider taking part.
Preventing progression in diabetic kidney disease13 June 2017Glitazones are drugs used to treat type 2 diabetes because they improve insulin resistance and reduce progression of associated kidney disease. But how do they work? The EBI’s Clinical Primer scheme for early-career clinicians has allowed a Bristol-based clinician, Dr Caroline Platt, to explore this question.
Novel targeting of disease causing cells could transform treatment of autoimmune diseases24 May 2017There is a problem with the traditional treatment of autoimmune and inflammatory conditions. Steroid therapy doesn’t always work, and immunosuppressant drugs can have toxic side effects. Bristol researchers, with the help of an award from the Elizabeth Blackwell Institute, are working to overcome this using novel ways of targeting disease causing cells.
Achievements of the Chronic Kidney Disease HIT in 2016-1723 May 2017One in ten people live with chronic kidney disease (CKD). This is a long-term condition that can increase the risk of heart disease or a sudden deterioration in kidney function, also known as acute kidney injury. The Chronic Kidney Disease Health Integration Team (CKD HIT) is a team of clinical staff and patients, working together to improve patient outcomes and care pathways for patients with kidney disease.
Bristol Bones and Joints highlights for 2016-1723 May 2017The Bones and Joints HIT covers three disease areas: osteoarthritis, osteoporosis and inflammatory rheumatological disorders, underpinned by three themes of patient self-management, patient and public involvement and information technology.
Bristol Immunisation Group’s highlights for 2016-1723 May 2017The Bristol Immunisation Group brings public health, clinical and academic experts together to improve the local performance and resilience of the national immunisation programmes. We also work to develop and deliver improvements through innovation and research.