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Potential New Way of Treating Diabetes

22 April 2016

A grant from the British Heart Foundation will explore new approaches to treating diabetes.

Dr Sebastian Oltean has been awarded £268,000 from the British Heart Foundation to explore why diabetes causes alternative splicing to go wrong in the kidneys and make the disease worse. Alternative splicing (the process which
turns sections of DNA into proteins) malfunctions in diabetics, causing abnormal proteins to be produced which can accelerate the complications of diabetes, including diabetic nephropathy which results in kidneys losing proteins in the urine. Seb will seek to better understand the mechanisms that go wrong will test ways of switching the production of damaging proteins back to beneficial ones. This knowledge could point the way to a completely new approach of treating diabetes. Nearly 3.5 million adults in the UK have been diagnosed with diabetes and an estimated half a million more are living with undiagnosed type 2. Diabetics are at higher risk of heart, circulatory and kidney disease, so providing a new target for the development of treatments which stop this process happening would benefit a significant number of people.

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