Measuring the masses – understanding human metabolism in health, ageing and disease

15 February 2018, 3.00 PM - 15 February 2018, 4.00 PM

Dr Warwick Dunn (Senior Lecturer in Metabolomics, Director of Mass Spectrometry, Phenome Centre Birmingham)

Room OS6, Second Floor, Oakfield House

Hosted by the MRC IEU.

Chair: George Davey Smith

Abstract: Metabolites have many important roles to play in human health, ageing and disease development/progression; these roles include metabolism, regulation/signalling and in cellular membrane structures. The study of metabolites on a global scale (metabolomics) is a growing scientific discipline being applied in biomedical research to understand these important metabolite roles and define phenotypic changes related to genetic and environmental influences. In this talk I will (1) introduce the role of metabolomics in biomedical research; (2) define why and how mass spectrometry is applied in metabolomics and (3) provide examples of how my research group and Phenome Centre Birmingham has applied metabolomics in endocrinology, musculoskeletal health and exercise interventions.

BiographyDr Warwick (Rick) Dunn’s research group focuses on developing innovative chromatography, mass spectrometry, sample collection and computational resources and their application in the study of the complex role of metabolites in human ageing and diseases (defined as metabolomics). Areas of biomedical study include endocrinology, inflammation and immunology including musculoskeletal health, cardio-renal diseases and complications of reproduction and pregnancy. Three key papers are defined below:

1. Dunn, W.B., et al.. Nature Protocols, 2011, 6(7), pp.1060-1083

2. Dunn, W.B., et al. Metabolomics, 2015, 11(1), pp.9-26.

3. Drogan, D., et al. Clinical Chemistry, 2015, 61(3), pp.487-497.

4. O’Reilly, M.W., et al. The Journal of Clinical Endocrinology & Metabolism, 2017, 102(9), pp.3327-3339.

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