Title TBC

30 October 2017, 1.00 PM - 30 October 2017, 2.00 PM

Margaret Cunningham (Institute Of Pharmacy And Biomedical Sciences, University of Strathclyde)

Lecture C42, Biomedical Sciences Building

Snapshots: Seminars in Physiology, Neuroscience and Pharmacology

Hosts: Alex Conibear/Stuart Mundell

I graduated with a First Class BSc (Hons) in Biochemistry and Pharmacology in 2006 from the University of Strathclyde. In 2010 I then completed an AJ Clark British Pharmacological Society (BPS)-funded PhD studentship in pharmacology and cell biology at Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). After a four year postdoctoral research position in the Bristol Platelet Group (University of Bristol), I returned to SIPBS in 2014 as an independent Strathclyde Chancellor’s Research Fellow to establish my own laboratory.

My field of expertise is G protein-coupled receptor (GPCR) regulation and function. GPCRs are membrane proteins that are involved in a variety of physiological processes ranging from roles in the regulation of mood, blood clotting, obesity, cancer, inflammation and pain. The focus of my research is identifying targets for the development new or improved anti-platelet therapies. One target of interest is the GPCR family called proteinase-activated receptors (PARs), which are known to regulate thrombin activity in hemostasis and thrombosis.

Two areas we are currently focusing on are:

  • Deciphering the protein interacting pathways that regulate PAR pharmacology to identify novel ways to regulate receptor activity for the development of new drugs.
  • Screening novel synthetic PAR modulators to assess their pharmacology and determine their use as inhibitors of platelet function.

Contact information

For futher information contact alex.conibear@bristol.ac.uk.

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