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Funding for research into link between oral and cardiac health

16 November 2017

Dr. Dáire Shanahan ( NIHR ACF in Oral Medicine), in collaboration with Dr. Angela Nobbs (Lecturer in Oral Microbiology),and Prof. Sarah George (Professor of Cardiovascular Signalling), has been awarded a  grant worth £16K from the David Telling Charitable Trust.

The project, entitled “The role of PPAR-delta in monocyte/macrophage behaviour and its link to the association of Aggregatibacter actinomycetemcomitans with atherosclerosis” is part of an ongoing collaboration between the Oral Microbiology group at Bristol Dental School and the Bristol Heart Institute.       

This study will improve our knowledge on whether the behaviour of monocytes with artery endothelium is altered following exposure to Aggregatibacter actinomycetemcomitans  in a way that would heighten the risk of atherosclerosis.

Studying the link between oral and cardiac health will allow a more holistic approach to patient care. It will highlight the importance of prevention, treatment and management of periodontal disease in suppressing atherosclerosis. Furthermore, it will pave the way to the introduction of novel therapies that can modulate disease progression. 

Further information

For further information about the study, please contact Dr Dáire Shanahan

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