The James Tudor Foundation Awards
CSNB awarded 2 grants by The James Tudor Foundation totalling £341,985
[Posted on 07 July 2006]
Professor Anthony Hollander - ARC Professor of Rheumatology and Tissue Engineering
We are delighted to announce that a grant of £257,139 has been awarded to Professor Anthony Hollander and his team for the purchase of a fluorescence activated cell sorter that can be used to isolate single cells labeled with a fluorescent tag. Professor Hollander will use this equipment in an attempt to clone telomerase positive stem cells from adult bone marrow. These cells will be used initially to study the biology of adult stem cells and subsequently for the treatment of orthopaedic diseases. This very generous grant was awarded by the Bristol-based charity, The James Tudor Foundation. Once it is established in the AMBI Research Laboratories at Southmead, FACS sorting will be provided as a service to other research groups in the Faculty
Professor Seth Love - Professor of Neuropathology
Alzheimer's disease is caused by the accumulation within the brain of a substance known as amyloid beta peptide (Aß). This peptide, which is damaging to nerve cells, accumulates to form amyloid plaques - large insoluble aggregates within the brain tissue - and it also deposits in the walls of blood vessels (causing an abnormality known as cerebral amyloid angiopathy). Scott Miners and other members of the Dementia Research Group in the Institute of Clinical Neurosciences recently demonstrated that patients with Alzheimer's disease are deficient in neprilysin, one of the enzymes responsible for the breakdown of Aß within the brain. Patrick Kehoe, Scott Miners and Seth Love are thrilled to announce that they have been awarded £84,846 by The James Tudor Foundation to establish the timing of loss of neprilysin activity in relation to the development of Alzheimer's disease, the relationship of loss of neprilysin to established risk factors for Alzheimer's disease and the potential for assaying levels of neprilysin in the cerebrospinal fluid.