Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis
Citation
Gray, E, Rice, C, Nightingale, H, Ginty, M, Hares, K, Kemp, K, Cohen, N, Love, S, Scolding, N & Wilkins, A, 2013, ‘Accumulation of cortical hyperphosphorylated neurofilaments as a marker of neurodegeneration in multiple sclerosis’. Multiple Sclerosis Journal, vol 19., pp. 153-161
Abstract
Axonal loss and grey matter neuronal injury are pathological processes that contribute to disease progression in multiple sclerosis (MS). Axon damage has been associated with changes in the phosphorylation state of neurofilaments and the presence of axonal spheroids. Perikaryal accumulation of abnormally phosphorylated neurofilament proteins has been reported in some neurodegenerative diseases.
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