Complexity from Simplicity: Tricyclic Aziridines from the Rearrangement of Pyrroles by Batch and Flow Photochemistry
Katie G. Maskill, Jonathan P. Knowles, Luke D. Elliott, Roger W. Alder, Kevin I. Booker-Milburn; Angew. Chem. Int. Ed., 2013, 52, 1499-1502
Molecular acrobatics: Irradiation of N-butenyl-substituted pyrroles that bear an electron-withdrawing group leads to complex tricyclic aziridines through an unprecedented photocycloaddition–rearrangement sequence. Gram quantities of these complex products could be produced by using a bespoke flow reactor (see picture, FEP=fluorinated ethylene propylene).