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Congratulations to Siying on winning poster prize

2 May 2017

CDT student Siying Zhong wins first prize at Syngenta poster competition

The annual Organic and Biological Section Syngenta Poster Competition for postgraduate students was held on Wednesday, 26th April 2017 with judges Matthew Hughes (Syngenta) and David Carbery (University of Bath) who were both extremely impressed with the exceptionally high quality and wide breadth of the chemistry presented.

Miss Siying Zhong (2014 Cohort), who is currently working under the joint supervision of Prof. Varinder Aggarwal and Dr Craig Butt, won 1st prize with her poster entitled Synergy of Computation, NMR and Synthesis Reveals True Baulamycin Structure.

The poster shows the configuration of a recently isolated polyketide Baulamycin A,3 which exhibits potent antibacterial activity, was reassigned using a combination of Density Functional Theory (DFT) calculations and synthesis. Comparison between the computed NMR parameters (H-H distances, H-H and H-C coupling constants) with the experimentally determined values eliminated 120 out of the possible 128 diastereomeric candidates. Finally, synthesis allowed the relative and absolute configurations of Baulamycin A to be positively identified.