Congenital heart disease (CHD)

What

As one of the leading centres in CHD, we are developing research capacity in the fields of myocardial responses to hypothermia and hypoxia in cardiac surgery, pulmonary hypertension, exercise physiology, inherited cardiac conditions and hypertension in coarctation. Our connections with the University of Bristol allow for basic science and a strong bench to bedside approach. Active collaboration is ongoing with University of Oxford, Imperial College- London, University College - London, and University of Heidleberg -Germany.

Where

Our team is based across the hospital trust, from fetal, paediatric cardiology at Bristol Royal Hospital for Children and for adults at the Bristol Heart Institute hospital.

How

We have translational projects from animal work, through basic science studies to clinical trial and outcomes. Our specific projects include

  • Pulmonary Hypertension
    • RV function in congenital heart disease
    • Wnt signaling in Downs syndrome
    • Drug trials of new medication
    • Inflammatory responses in airways
    • Pulmonary blood flow in the Fontan circuit
  • Responses of the myocardium to cardiopulmonary bypass
    • Effect of cool and warm cardioplegia
    • Protective effect of phosphodiesterase inhibitors
  • Effect of exercise and re-training on congenital heart disease
  • Coarctation of the aorta and vascular stiffness
  • Kawasaki disease in the UK population
  • Protocols for resuscitation of Children in emergency

More information

Further details on research in congenital heart disease can be found by visiting pages of key researchers in this field

Edit this page