Approximately a quarter of a million patients suffer a heart attack (or myocardial infarction, MI) in the UK each year, and around 120,000 of these die.
MI is caused by the formation of a blood clot (thrombosis) superimposed on a ruptured or surface-eroded coronary atherosclerotic plaque. This process is called atherothrombosis (illustrated in the image above).
Identifying the causes and devising new treatments for these ‘vulnerable’ plaques are internationally recognised priorities, and are at the heart of our research.
We have made major contributions to understanding how arterial smooth muscle cells behave and how these behaviours contribute to atherogenesis and to vein graft failure. Our research has also greatly increased our understanding of matrix degrading metalloproteinases in weakening the plaque extracellular matrix and the pathways that regulate their production.
Similarly, we conduct world-leading research on the molecular biology of vascular smooth muscle cells that repair such injuries, and on the causes of endothelial dysfunction, which predisposes patients - particularly those with diabetes - to MI. (Image right shows endothelial cells regrowing into an injured artery.)
Finally, we have made groundbreaking discoveries in the area of platelet biology, as these platelet producing blood cells (see image top right) are at the centre of the developing thrombus that blocks the vessel. We have identified a number of genes that regulate these cells, and have identified mutations in some of these genes that underlie platelet dysfunction in man.
Research is conducted mostly by people in the School of School of Physiology, Pharmacology and Neuroscience , and the School of Clinical Sciences.
Characteristic methods and techniques routinely used in this area of research include:
Current projects include:
Further details on research into atherothrombosis can be found at: