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Translational Biomedical Research Centre

14 June 2016

TBRC will use experimental models highly relevant to human disease and anatomy to test approaches, devices or therapies in a stateof-the art animal hospital theatre operating at NHS standards.

The TBRC is a new national centre unique in Europe. On 9 June 2016 the £6.2M Centre, funded by the University of Bristol, the Medical Research Council (MRC) and the British Heart Foundation (BHF) was opened by MRC Chief Science Officer Dr Declan Mulkeen and BHF Medical Director Prof Peter Weissberg. Translational medicine takes in vitro lab science and aims to prove it has positive effects on a whole organism. Prior to human trials, new discoveries are tested in animals to ensure safety and beneficial health outcomes, e.g. to test new medical devices such as heart valves, vascular stents, joint replacement prostheses, instrumentation used for key-hole surgery, devices to deliver new drugs in patients or to test novel drugs and stem cells.

Results of any interventions will be tracked in living animals using scanners, which will allow researchers to develop new treatments and interventions whilst reducing the number of animals needed as they are able to monitor animals over time. During and after treatments animals will be treated by specialists who will ensure the highest standards of animal welfare and reproducibility of the procedures. The centre will also have a bio-bank on site which will reduce the future need for animal tissue samples. TBRC will operate under the One Health concept that recognises the health of humans is connected to the health of animals and the environment, meaning that some research could benefit animals in equal measure. Veterinary clinicians will develop new methods to treat animals, which often could be as simple as adapting treatments already established in humans. For further information, a meeting or a tour of the facility, contact tbrc@bristol.ac.uk

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