Research Seminar: Dr Roberto Feuda - University of Bristol
Dr Roberto Feuda hosted Professor Davide Pisani
Life Sciences Seminar Room G13/G14
Toward a system-level understanding of the evolution of the nervous system
The developmental specification of neurons is a system-level problem that requires the coordinate expression of hundreds of genes. This process is controlled by the interaction of regulatory genes, known as gene regulatory networks (GRNs). In this talk, I will initially focus on the identification of the GRNs that pattern the neurons in the sea urchin apical domain. To this aim, I will describe the spatial and temporal expression of over 30 regulatory genes, and I will discuss how this information is used to prioritize gene perturbations and to identify the GRNs. In the second part of the talk, I will discuss the evolutionary implications of my findings for neurogenesis in Bilateria.
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