Research Seminar: Dr Alexei Maklakov - University of East Anglia

8 October 2018, 1.00 PM - 8 October 2018, 2.00 PM

Dr Alexei Maklakov hosted by Dr Sinead English

Life Sciences Seminar Room G13/G14

Title:

Why Do Organisms Age: Beyond Energy Trade-Offs

Abstract:

Recent breakthroughs in the biology of ageing have challenged the long-standing paradigm that energy trade-offs between reproduction and longevity underlie organismal senescence. Specifically, experimental downregulation of nutrient-sensing signalling pathways that govern biosynthesis in response to nutrient availability can achieve increased longevity without reduced reproduction. The emerging new theory of ageing provides a conceptually novel framework for these paradoxical findings by proposing that ageing is a direct consequence of physiological processes optimized for early-life function, such as growth and early-life reproduction, that are running ‘too high’ (i.e. at hyperfunction) in late adulthood. Contrary to the classic view based on energy allocation trade-offs, the hyperfunction theory predicts that health, longevity and Darwinian fitness can be simultaneously improved by optimizing nutrient-sensing signalling in late-life. I will discuss these ideas in the context of the classic evolutionary theory of ageing, and show some unpublished experimental data testing these ideas in Caenorhabditis nematodes.

Contact information

Please contact lsb-admin@bristol.ac.uk if you have any queries.

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