11 October 2018, 4.00 PM - 11 October 2018, 5.00 PM
Prof. Laurence Pearl FRS FMedSci (University of Sussex)
Title: Phosphorylation-dependent assembly of the DNA damage response
Followed by wine reception outside E29
Survival of major DNA damage caused by ionising radiation or genotoxic stress, requires a coordinated cellular response in which the damage is recognised and the cell cycle halted to allow repair to be completed. This DNA Damage Response involves assembly of substantial multi-protein complexes organised around a set of large ‘scaffold’ proteins, including BRCA1, MDC1, 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins, and are themselves carriers of such regulatory signals. My laboratory is studying how these post-translational modification, especially phosphorylation, provide the signals for assembly of the multi-protein complexes that mediate DNA damage signalling and repair. I will discuss published work on assembly of DNA damage checkpoint complexes, and present new data on phosphorylation-dependent collaborations between scaffold proteins, that have major regulatory roles in preventing replication in the presence of unprepared DNA damage.
Hosted by Imre Berger