Lorna Hale
Current Position: BSc, CLIC Research Technician, Institute of Child Life and Health, Clinical Sciences South Bristol, University of Bristol (appointed Jan 2005).
Qualifications: BSc (Hons) Biochemistry with Molecular Biology, Cardiff University.
Research Interests: Epigenetic mechanisms of resistant disease in childhood leukaemia
I have been working as part of the Paediatric Oncology Therapeutics Group (POET) since the beginning of 2005. We are interested in the epigenetic mechanisms behind the onset of drug resistance in childhood leukaemia. The main focus of my work so far has been to look at the drug resistance properties of a number of leukaemia cell lines, using a range of different techniques, including in vitro cell culture and colorimetric assays. In the near future I will be extending this work to incorporate the analysis of donated patient samples to explore possible connections between hypotheses postulated from my current data and actual occurences within the cells of patients.
Publications and Posters:
H.M.Martin, L.J.Hale, P.R.Kearns. 5-Aza-2'-Deoxycytidine and Valproic Acid Induce Changes in Multi-Drug Resistance Profiles in Leukaemia Cell Lines. Poster presentation at International Society for Experimental Hematology, Glasgow 2005.