Dr Lisa Gray
Lisa Clare Gray (nee Bloodworth)
Current Post LRF Post-Doctoral Research Assistant in the Immunogenetics Group, Department of Pathology and Microbiology, University of Bristol, (appointed January 2004).
Qualifications MBiochem (Bath), PhD (Newcastle Upon Tyne).
I have been working in the Immunogenetics group since January 2004. We are currently undertaking a study looking into polymorphisms and mutations in the NF-kB/IkB pathway, in multiple myeloma with an aim to looking at associations with disease status and progression-free/overall survival. The general theme of the research in this laboratory has been in the invesigation of cytokine gene polymorphisms in a range of diseases. For polymorphism detection we use induced heteroduplex generator (IHG) technology, a novel genotyping method, which can unequivocally distinguish homozygotes from heterozygotes and mutation screening has been undertaken using a combination of denaturing HPLC (WAVE™) and DNA sequencing.
*Spink C.F., *Gray L.C., Davies F.E., Morgan G.J., Bidwell J.L. “Haplotypic structure across the I?B? gene and association with multiple myeloma” in preparation to be submitted to Int. J. Cancer (* equal contribution).
Irving J.A.E., Bloodworth L., Bown N.P., Case M.C., Hogarth L.A., HallA.G., “Loss of heterozygosity in childhood acute lymphoblastic leukaemiadetected by genome-wide microarray single nucleotide polymorphismanalysis” Cancer Research (2005) 65 (8) pp3053-3058.
“Role of mismatch repair deficiency in determining sensitivity to thetopoiomerase II poisons” - Proceedings of 94th Annual meeting of theAmerican Association for Cancer Research (Washington, July 2003).
“Role of mismatch repair deficiency in determining sensitivity to the topoiomerase II poisons” presented at the British Association for Cancer Research (BACR) Meeting, Bournemouth, July 2003.
M.S.Cragg, W.J. Howatt, L. Bloodworth, V.A. Anderson, B.P. Morgan, M.J.Glennie."Complement mediated cell death is associated with DNA fragmentation." Cell Death and Differentiation (2000) 7 pp49-58.