One Health drivers of antibacterial resistance in Thailand
This project aims to develop an understanding of the One Health drivers of AMR in rural Thailand (OH-DART).
What is the problem?
Antibacterial drug resistance (ABR) is a significant source of excess mortality in Overseas Development Assistance (ODA) countries. AMR (predominantly ABR) is estimated to have caused 38,000 deaths and an economic loss of 1.2 billion US$ in Thailand in 2010. ABR is common in human, environmental and animal bacterial isolates, where tested.
The Thai National Strategic Plan on AMR (2017-2022) has been developed to reduce ABR. Strategies include a “One Health” AMR surveillance system; regulation of antimicrobial (AM) distribution; better infection prevention and control and AM stewardship in humans, agriculture and companion animals; improved public knowledge on AMR and awareness of appropriate AM use; governance mechanisms to develop and sustain AMR-related actions.
Because of good record keeping and surveillance, Thailand has been used as an exemplar for characteristics of ABR in ODA countries. ABR is common in human, environmental and animal bacterial isolates. However, ABR has mostly been studied separately in discrete sectors (e.g. hospital patients or poultry). The key drivers of ABR relevant to human health cannot be pinpointed in this way because the selection and transmission of ABR results from interactions between humans, animals, and the environment. A "One Health" approach to the problem is required.
What is the research being carried out?
We will study the Enterobacteriaceae family bacteria Klebsiella pneumoniae and Escherichia coli, which reside in the human and animal gut, are common in environments contaminated with faeces, and are considered a significant threat to human health in Thailand. They are commonly carbapenem- and/or 3rd generation cephalosporin-resistant (3GCR), which are drugs commonly used for serious infections.
Our consortium's vision is to build a holistic picture of the drivers of ABR in Thailand and to use this information to benefit the Thai people, and as an exemplar for other ODA countries. The term "driver" may refer to: 1) a material condition or substance, such as a chemical (e.g. an Antibiotic), which, at a particular concentration, selects for the increased prevalence of ABR bacteria; 2) an action, such as exposing bacteria to that chemical by taking an antibiotic; or 3) a socioeconomic condition or circumstance which accounts for that action (e.g. the economic necessity to keep working in the face of illness). A full understanding of ABR drivers at every level is important for the design of effective and appropriate interventions to limit ABR. Hence, this interdisciplinary consortium will investigate them all.
Outcome and next steps
The project will enter sample collection stage in November 2018
Prof Matthew Avison discusses the new £2.9m GCRF award aimed at tackling antibacterial resistance in Thailand.
- Prof Matthew Avison (School of Cellular and Molecular Medicine)
- Dr Kristen Reyher (Bristol Veterinary School)
- Dr Katy Turner (Bristol Veterinary School)
- Prof Helen Lambert (Bristol Medical School)
- Prof Ed Feil (University of Bath)
- Prof Henry Buller (University of Exeter)
- Dr Emma Pitchforth (University of Exeter)
- Dr Andrew Singer (NERC Centre for Ecology and Hydrology)
- Prof Skorn Mongkolsuk (Chulabhorn Research Institute, Bangkok)
- Dr Jutamaad Satayavivad (Chulabhorn Research Institute, Bangkok)
- Prof Visanu Thamlikitikul (Mahidol University, Bangkok)
- Prof Parntep Ratanakorn (Mahidol University, Bangkok)
- Prof Luechai Sringernyuang (Mahidol University, Bangkok)
- Dr Aronrag Meeyai (Mahidol University, Bangkok)
- Tackling AMR - A Cross Council Initiative MRC/DoH-led ‘AMR in a Global Context’ development and full awards
Prof Matthew Avison
Tel: +44 (0)117 33 12064